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Indications and usage: Luzu (Luliconazole) cream, 1% is an azole antifungal indicated for the topical treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum and Epidermophyton floccosum. Dosage and administration: Dosage forms and strengths: Luzu, Ludura (Luliconazole) cream 1%. Contraindications: None. Mechanism of action: Luliconazole is an antifungal that belongs to the azole class. Although the exact mechanism of action against dermatophytes is unknown, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase. Inhibition of this enzyme's activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol. Drug interactions: An in vivo study in adult subjects with moderate to severe interdigital tinea pedis and tinea cruris showed that Luzu cream is mostly a weak inhibitor of CYP2C19. In a separate trial in adolescent subjects with tinea cruris, in vivo blood levels of Luliconazole cream, were seen to approach those levels sufficient to show moderate inhibition of CYP2C19. Adverse reactions, side effects: The most common adverse reactions observed in clinical trials of luliconazole cream were application site reactions, which occurred in less than 1% of subjects. To report suspected adverse reactions of Luzu (Luliconazole) cream 1% contact Bausch Health US, LLC or your local FDA. Patient counseling information: Inform patients that Luzu cream 1% is for topical use only. Luliconazole cream is not intended for intravaginal or ophthalmic use. Where to buy luliconazole online: To purchase Luzu (Luliconazole) cream 1% w/w in tubes 20 g from reliable online pharmacies and drugstores please use resources described above on this webpage. |