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Indications and usage:

Addyi (Flibanserin) is indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOTdue to:

  • A co-existing medical or psychiatric condition,
  • Problems within the relationship, or
  • The effects of a medication or other drug substance.

    Limitations of use:

  • Addyi (Flibanserin) is not indicated for the treatment of HSDD in postmenopausal women or in men.
  • This medication is not indicated to enhance sexual performance.


    Dosage and administration:

  • Recommended dosage is 100 mg taken once daily at bedtime.
  • Flibanserin (Addyi) is dosed at bedtime because administration during waking hours increases risks of hypotension, syncope, accidental injury, and central nervous system (CNS) depression.
  • Discontinue treatment after 8 weeksif no improvement.


    Dosage forms and strengths:

    Addyi (Flibanserin) oral tablets 100 mg.


    Overdosage:

    Overdosage of flibanserin may cause an increase in the incidence or severity of any of the reported adverse reactions. In the event of overdosage, treatment should address the symptoms and supportive measures, as needed. There is no known specific antidote for Addyi.


    Contraindications:

  • Moderate or strong cytochrome P450 3A4 (CYP3A4) inhibitors.
  • Hepatic impairment.


    Warnings and precautions:

  • Hypotension and syncope with ADDYI alone: patients with pre-syncope should immediately lie supine and promptly seek medical help if symptoms do not resolve.
  • Central nervous system (CNS) depression (e.g., somnolence, sedation): can occur with flibanserin alone. Exacerbated by other CNS depressants, and in settings where Addyi concentrations are increased. Patients should avoid activities requiring full alertness (e.g., operating machinery or driving) until at least 6 hours after each dose and until they know how this medication affects them.


    Adverse reactions, side effects:

    Most common adverse reactions (incidence >= 2%) are dizziness, somnolence, nausea, fatigue, insomnia, and dry mouth.


    Drug interactions:

  • Oral contraceptives and other weak CYP3A4 inhibitors: increases flibanserin exposures and incidence of adverse reactions.
  • Strong CYP2C19 inhibitors: increases flibanserin exposure which may increase risk of hypotension, syncope, and CNS depression.
  • CYP3A4 inducers: use of Addyi not recommended; flibanserin concentrations substantially reduced.
  • Digoxin: increases digoxin concentrations, which may lead to digoxin toxicity. Increase monitoring of digoxin concentrations.

    Related medications:

    Diazepam (Valium)


    Use in specific populations:

  • Nursing Mothers: flibanserin is not recommended.
  • CYP2C19 poor metabolizers: increases Addyi exposure which may increase risk of hypotension, syncope, and CNS depression.


    Where to buy flibanserin online:

    To purchase Flibanserin HCl (Addyi) 100 mg tablets from reliable online pharmacies and drugstores please use resources described above on this webpage.

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