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Buy Tolvaptan (Samsca) online on NC-CME
Tolvaptan (trade names include Samsca, Jinarc, Jynarque, Natrise, Resodim, Tolvat, Vaptan) is an aquaretic drug, diuretic medication from vasopressin antagonists pharmacological group. This medicine is used for the treatment of low blood sodium levels (hyponatremia) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). It works as a selective, competitive vasopressin receptor 2 (V2) antagonist.
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Pharmacological and medical categories:
Vasopressin V2-receptor antagonist
C - Cardiovascular system
C03 - Diuretics
C03X - Other diuretics
C03XA - Vasopressin antagonists
C03XA01 - Tolvaptan
Hyperfunction of pituitary gland - E22
Syndrome of inappropriate secretion of antidiuretic hormone - E22.2
Other disorders of fluid, electrolyte and acid-base balance - E87
Hypo-osmolality and hyponatremia - E87.1
Heart failure - I50
Fibrosis and cirrhosis of liver - K74
Indications and usage:
Samsca (Tolvaptan) is a selective vasopressin V2-receptor antagonist indicated for the treatment of clinically significant hypervolemic and euvolemic hyponatremia [serum sodium < 125 mEq/L or less marked hyponatremia that is symptomatic and has resisted correction with fluid restriction], including patients with heart failure and Syndrome of Inappropriate Antidiuretic Hormone (SIADH).
Patients requiring intervention to raise serum sodium urgently to prevent or to treat seriousneurological symptoms should not be treated with Samsca.
It has not been established that Tolvaptan provides a symptomatic benefit to patients.
Dosage and administration:
Samsca (Tolvaptan) should be initiated and re-initiated in a hospital.
The recommended starting dose is 15 mg once daily. Dosage may be increased at intervals >= 24 hr to 30 mg once daily, and to a maximum of 60 mg once daily as needed to raise serum sodium.
Dosage forms and strengths:
Tolvaptan tablets: 15 mg and 30 mg
Use in patients with autosomal dominant polycystic kidney disease (ADPKD) outside of FDA-approved REMS
Need to raise serum sodium acutely
Patients who are unable to respond appropriately to thirst
Concomitant use of strong CYP3A inhibitors
Adverse reactions, side effects:
Most common adverse reactions ( >= 5% placebo) are thirst, dry mouth, asthenia, constipation, pollakiuria or polyuria, and hyperglycemia.
B3 - Australia
C - United States (Risk cannot be ruled out)
Salts and other forms:
Synonyms, international and chemical names:
Brands, generics, trade names:
Jinarc - Otsuka Pharmaceutical
Jynarque - Otsuka Pharmaceutical
Natrise - Sun Pharmaceutical Industries
Resodim - Lupin
Samsca - Otsuka Pharmaceutical
Tenax - Edallia Pharmaceuticals
Tolaqua - Abhay Pharma
Tolsama - MSN Laboratories, Mutual Medical Agencies
Tolvaptoris - Steris Healthcare
Tolvasca - Glenmark Pharmaceuticals, Mili Health Care
Tolvat - MSN Laboratories, Shaurya Internationa
Tvaptan - Lahar Pharmaceuticals
Vaptan - Steadfast MediShield
Updated: February 2020
Reviewed: February 2020