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Buy Tolvaptan (Samsca) online on NC-CME
Tolvaptan (trade names include Samsca, Jinarc, Jynarque, Natrise, Resodim, Tolvat, Vaptan) is an aquaretic drug, diuretic medication from vasopressin antagonists pharmacological group. This medicine is used for the treatment of low blood sodium levels (hyponatremia) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). It works as a selective, competitive vasopressin receptor 2 (V2) antagonist.

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Type: Samsca (Tolvaptan) generic
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Related medications:

  • Amiloride + Furosemide (Frumil)
  • Atenolol (Tenormin)
  • Conivaptan (Vaprisol)
  • Enalapril (Vasotec)
  • Furosemide (Lasix)
  • Hydrochlorothiazide (Microzide)
  • Metoprolol (Lopressor)
  • Prazosin (Minipress)
  • Propranolol (Inderal)
  • Torsemide (Demadex)
  • Valsartan (Diovan)


    Pharmacological and medical categories:

  • Aquaretic drugs
  • Diuretics
  • Vasopressin V2-receptor antagonist
  • Water pills
  • Water tablets


    ATC codes:

  • C - Cardiovascular system
  • C03 - Diuretics
  • C03X - Other diuretics
  • C03XA - Vasopressin antagonists
  • C03XA01 - Tolvaptan


    ICD-10 codes:

  • Hyperfunction of pituitary gland - E22
  • Syndrome of inappropriate secretion of antidiuretic hormone - E22.2
  • Other disorders of fluid, electrolyte and acid-base balance - E87
  • Hypo-osmolality and hyponatremia - E87.1
  • Heart failure - I50
  • Fibrosis and cirrhosis of liver - K74


    Indications and usage:

    Samsca (Tolvaptan) is a selective vasopressin V2-receptor antagonist indicated for the treatment of clinically significant hypervolemic and euvolemic hyponatremia [serum sodium < 125 mEq/L or less marked hyponatremia that is symptomatic and has resisted correction with fluid restriction], including patients with heart failure and Syndrome of Inappropriate Antidiuretic Hormone (SIADH).

    Important Limitations:

  • Patients requiring intervention to raise serum sodium urgently to prevent or to treat seriousneurological symptoms should not be treated with Samsca.
  • It has not been established that Tolvaptan provides a symptomatic benefit to patients.


    Dosage and administration:

  • Samsca (Tolvaptan) should be initiated and re-initiated in a hospital.
  • The recommended starting dose is 15 mg once daily. Dosage may be increased at intervals >= 24 hr to 30 mg once daily, and to a maximum of 60 mg once daily as needed to raise serum sodium.


    Dosage forms and strengths:

    Tolvaptan tablets: 15 mg and 30 mg


    Contraindications:

  • Use in patients with autosomal dominant polycystic kidney disease (ADPKD) outside of FDA-approved REMS
  • Need to raise serum sodium acutely
  • Patients who are unable to respond appropriately to thirst
  • Hypovolemic hyponatremia
  • Concomitant use of strong CYP3A inhibitors
  • Anuria
  • Hypersensitivity


    Adverse reactions, side effects:

    Most common adverse reactions ( >= 5% placebo) are thirst, dry mouth, asthenia, constipation, pollakiuria or polyuria, and hyperglycemia.


    Pregnancy categories:

  • B3 - Australia
  • C - United States (Risk cannot be ruled out)


    Salts and other forms:

  • Tolvaptan Base


    Synonyms, international and chemical names:

  • Tolvaptana
  • Tolvaptano
  • Tolvaptanum


    Brands, generics, trade names:

  • Jinarc - Otsuka Pharmaceutical
  • Jynarque - Otsuka Pharmaceutical
  • Natrise - Sun Pharmaceutical Industries
  • Resodim - Lupin
  • Samsca - Otsuka Pharmaceutical
  • Tenax - Edallia Pharmaceuticals
  • Tolaqua - Abhay Pharma
  • Tolsama - MSN Laboratories, Mutual Medical Agencies
  • Tolvaptoris - Steris Healthcare
  • Tolvasca - Glenmark Pharmaceuticals, Mili Health Care
  • Tolvat - MSN Laboratories, Shaurya Internationa
  • Tvaptan - Lahar Pharmaceuticals
  • Vaptan - Steadfast MediShield


    Updated: February 2020
    Reviewed: February 2020
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