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Luliconazole (trade names include Luzu, Ludura, Luitor, Lulican, Lulidila, Lulifin, Luliford, Luzarn, Zyluli) is a topical antifungal medication from imidazole and triazole derivatives pharmacological group. This medicine is used for the treatment of jock itch, athlete's foot, and ringworm caused by dermatophytes such as Epidermophyton floccosum, Microsporum gypseum, Trichophyton rubrum.
Betamethasone + Clotrimazole (Lotrisone)
Bifonazole (Canesten Once Daily)
Chlormidazole + Fluocinolone (Mycosynalar)
Clotrimazole (Gyne-Lotrimin, Mycelex-G)
Pharmacological and medical categories:
Imidazole antifungal medications
Topical antifungals and antiparasites
D - Dermatologicals
D01 - Antifungals for dermatological use
D01A - Antifungals for topical use
D01AC - Imidazole and triazole derivatives
D01AC18 - Luliconazole
Dermatophytosis - B35
Tinea barbae and tinea capitis - B35.0
Tinea unguium - B35.1
Tinea pedis - B35.3
Tinea cruris - B35.6
Dermatophytosis, unspecified - B35.9
Indications and usage:
Luzu (Luliconazole) cream, 1% is an azole antifungal indicated for the topical treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum and Epidermophyton floccosum.
Dosage and administration:
For topical use only. Not for ophthalmic, oral, or intravaginal use.
Interdigital Tinea Pedis: Luliconazole (Luzu) cream, 1% should be applied to the affected and immediate surrounding area(s) once a day for 2 weeks.
Tinea Cruris and Tinea Corporis: this medication should be applied to the affected skin and immediate surrounding area(s) once a day for 1 week.
Dosage forms and strengths:
Luzu (Luliconazole) cream 1%.
Mechanism of action:
Luliconazole is an antifungal that belongs to the azole class. Although the exact mechanism of action against dermatophytes is unknown, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase. Inhibition of this enzyme's activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol.
An in vivo study in adult subjects with moderate to severe interdigital tinea pedis and tinea cruris showed that Luzu cream is mostly a weak inhibitor of CYP2C19. In a separate trial in adolescent subjects with tinea cruris, in vivo blood levels of Luliconazole cream, were seen to approach those levels sufficient to show moderate inhibition of CYP2C19.
Adverse reactions, side effects:
The most common adverse reactions observed in clinical trials were application site reactions, which occurred in less than 1% of subjects.
To report suspected adverse reactions, contact Bausch Health US, LLC or your local FDA.
Patient counseling information:
Inform patients that Luzu cream 1% is for topical use only. Luliconazole cream is not intended for intravaginal or ophthalmic use.
B3 - Australia
C - United States (Risk cannot be ruled out)
Salts and other forms:
Synonyms, international and chemical names:
Brands, generics, trade names:
Ludura - Cipla
Lufungal - Dawson Healthcare Solutions
Luitor - Torque Pharmaceuticals
Lulican - Glenmark Pharmaceuticals
Lulicon - Sun Pharmaceutical Industries
Luliconaz - Healing Pharma
Lulidila - Cadila Pharmaceuticals
Lulifin - Sun Pharmaceutical Industries
Luliford - Leeford Healthcare
Luliken - Kenvish Healthcare
Lulikon - Ridley Life Science
Lulimark - Nimbles Biotech
Lulisign - HAB Pharmaceuticals & Research
Lulitris - Doctris Life Sciences
Luly - Brinton Pharmaceuticals
Lulyera - Yash Pharma Laboratories
Luvius - Johnlee Pharmaceuticals
Luzarn - Emcure Pharmaceuticals
Luzu - Bausch and Lomb
Zyluli - Zydus Cadila
Zylulin - Zirex Pharma
Luliconazole main article on Wikipedia: https://en.wikipedia.org/wiki/Luliconazole
Luliconazole compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Luliconazole
Luliconazole on DrugBank: https://go.drugbank.com/drugs/DB08933
Luliconazole FAQ on MedlinePlus (revised 02/15/2017): https://medlineplus.gov/druginfo/meds/a614020.html
Luzu (Luliconazole) cream drug label info on DailyMed (revised April 1, 2020): https://dailymed.nlm.nih.gov/dailymed/lookup...
Luliconazole for sale on Pharma Doctor: https://pharma-doctor.com/luliconazole.html
Luzu (Luliconazole) cream 1% for topical use official prescribing and patient information from the U.S. FDA (revised 02/2017): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Luzu (Luliconazole) cream 1% for topical use official prescribing and patient information from Bausch Health pharmaceutical company (revised 04/2020): https://www.bauschhealth.com/Portals/25/Pdf/PI/Luzurx-PI.pdf
Ludura (Luliconazole) cream and lotion 1% prescribing information from Cipla pharmaceutical company (revised May 2017): https://www.ciplamed.com/content/ludura-cream-lotion
Revised: March 2021